Clinical relevance of stroke models.

Current Concepts of Cerebrovascular Disease — Stroke Clinical Relevance of Models of Cerebral Ischemia

A MAJOR CONSIDERATION in the evaluation of experimental models of ischemic stroke in animals is the clinical relevance of the models. Difficulties arise in relating studies of models of focal cerebral ischemia to the clinical situations of strokes in humans because of many factors, including species differences, the effects of anesthesia, and the progressive nature of atherosclerosis. However, ...

Stroke mimics in patients with clinical signs of stroke

Background: Stroke mimic is a major diagnostic challenge and may be difficult to distinguish from real strokes. The aim of this study was to evaluate the relative frequency of stroke mimics in patients with clinical signs of stroke. Methods: In this cross sectional-study, the medical records of 1985 patients with stroke admitted to Poursina Hospital were enrolled using the census technique. ...

Stroke-induced immunodepression: experimental evidence and clinical relevance.

Stroke affects the normally well-balanced interplay of the 2 supersystems: the nervous and the immune system. Recent research elucidated some of the involved signals and mechanisms and, importantly, was able to demonstrate that brain-immune interactions are highly relevant for functional outcome after stroke. Immunodepression after stroke increases the susceptibility to infection, the most rele...

Clinical relevance of experimental models of acute pancreatitis

Ischemic preconditioning in humans: models, mediators, and clinical relevance.

Ischemic preconditioning, a powerful form of endogenous protection against myocardial infarction, has been demonstrated in several animal species and, recently, in isolated human cardiomyocytes. For both logistic and ethical reasons, no clinical study can meet the strict conditions of experimental studies on preconditioning with infarct size as the end-point. Nevertheless, the demonstration of ...